ExplorEnz: EC 1.14.11.64

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1.14.11.64

Accepted name:

glutarate dioxygenase

Reaction:

glutarate + 2-oxoglutarate + O₂ = (S)-2-hydroxyglutarate + succinate + CO₂

Other name(s):

csiD (gene name)

Systematic name:

glutarate, 2-oxoglutarate:oxygen oxidoreductase ((S)-2-hydroxyglutarate-forming)

Comments:

Requires iron(II). The enzyme, characterized from the bacteria Escherichia coli and Pseudomonas putida, participates in L-lysine degradation in many bacteria. It provides an alternative route for L-glutarate degradation that does not proceed via CoA-activated intermediates.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Knorr, S., Sinn, M., Galetskiy, D., Williams, R.M., Wang, C., Muller, N., Mayans, O., Schleheck, D. and Hartig, J.S. Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate. Nat. Commun. 9:5071 (2018). [PMID: 30498244]
2.	Zhang, M., Gao, C., Guo, X., Guo, S., Kang, Z., Xiao, D., Yan, J., Tao, F., Zhang, W., Dong, W., Liu, P., Yang, C., Ma, C. and Xu, P. Increased glutarate production by blocking the glutaryl-CoA dehydrogenation pathway and a catabolic pathway involving L-2-hydroxyglutarate. Nat. Commun. 9:2114 (2018). [PMID: 29844506]

[EC 1.14.11.64 created 2019]