| EC |
1.14.14.113 |
| Accepted name: |
α-humulene 10-hydroxylase |
| Reaction: |
α-humulene + O2 + [reduced NADPH—hemoprotein reductase] = 10-hydroxy-α-humulene + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of zerumbone biosynthesis, click here |
| Other name(s): |
CYP71BA1 |
| Systematic name: |
α-humulene,[reduced NADPH—hemoprotein reductase]:oxygen 10-oxidoreductase |
| Comments: |
A cytochrome P-450 (heme-thiolate) protein. The recommended numbering of humulene gives 10-hydroxy-α-humulene as the product rather than 8-hydroxy-α-humulene as used by the reference. See Section F: Natural Product Nomenclature. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Yu, F., Okamoto, S., Harada, H., Yamasaki, K., Misawa, N. and Utsumi, R. Zingiber zerumbet CYP71BA1 catalyzes the conversion of α-humulene to 8-hydroxy-α-humulene in zerumbone biosynthesis. Cell. Mol. Life Sci. 68 (2011) 1033–1040. [DOI] [PMID: 20730551] |
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| [EC 1.14.14.113 created 2012 as EC 1.14.13.150, transferred 2018 to EC 1.14.14.113] |
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