| EC |
1.14.14.136 |
| Accepted name: |
deoxysarpagine hydroxylase |
| Reaction: |
10-deoxysarpagine + [reduced NADPH—hemoprotein reductase] + O2 = sarpagine + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of geissoschizine and sarpagine biosynthesis, click here |
| Other name(s): |
DOSH |
| Systematic name: |
10-deoxysarpagine,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (10-hydroxylating) |
| Comments: |
A cytohrome P-450 (heme-thiolate) protein isolated from the plant Rauvolfia serpentina. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Yu, B., Ruppert, M. and Stöckigt, J. Deoxysarpagine hydroxylase — a novel enzyme closing a short side pathway of alkaloid biosynthesis in Rauvolfia. Bioorg. Med. Chem. 10 (2002) 2479–2483. [DOI] [PMID: 12057637] |
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| [EC 1.14.14.136 created 2005 as EC 1.14.13.91, transferred 2018 to EC 1.14.14.136] |
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