ExplorEnz: EC 1.14.19.74

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1.14.19.74

Accepted name:

(+)-piperitol/(+)-sesamin synthase

Reaction:

(1) (+)-pinoresinol + [reduced NADPH-hemoprotein reductase] + O₂ = (+)-piperitol + [oxidized NADPH-hemoprotein reductase] + 2 H₂O
(2) (+)-piperitol + [reduced NADPH-hemoprotein reductase] + O₂ = (+)-sesamin + [oxidized NADPH-hemoprotein reductase] + 2 H₂O

For diagram of sesamin biosynthesis, click here

Other name(s):

CYP81Q1; CYP81Q2; PS; PSS; SS; piperitol synthase; sesamin synthase

Systematic name:

(+)-pinoresinol,[reduced NADPH-hemoprotein reductase]:oxygen oxidoreductase (cyclizing)

Comments:

A cytochrome P-450 (heme-thiolate) protein. Isolated from Sesamum indicum (sesame) and S. radiatum (black sesame).

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Ono, E., Nakai, M., Fukui, Y., Tomimori, N., Fukuchi-Mizutani, M., Saito, M., Satake, H., Tanaka, T., Katsuta, M., Umezawa, T. and Tanaka, Y. Formation of two methylenedioxy bridges by a Sesamum CYP81Q protein yielding a furofuran lignan, (+)-sesamin. Proc. Natl. Acad. Sci. USA 103 (2006) 10116–10121. [PMID: 16785429]

[EC 1.14.19.74 created 2018]