EC	1.8.4.2
Accepted name:	protein-disulfide reductase (glutathione)
Reaction:	2 glutathione + protein-disulfide = glutathione-disulfide + protein-dithiol
Other name(s):	glutathione-insulin transhydrogenase; insulin reductase; reductase, protein disulfide (glutathione); protein disulfide transhydrogenase; glutathione-protein disulfide oxidoreductase; protein disulfide reductase (glutathione); GSH-insulin transhydrogenase; protein-disulfide interchange enzyme; protein-disulfide isomerase/oxidoreductase; thiol:protein-disulfide oxidoreductase; thiol-protein disulphide oxidoreductase
Systematic name:	glutathione:protein-disulfide oxidoreductase
Comments:	Reduces insulin and some other proteins.
References:	1.  Katzen, H.M., Tietze, F. and Stetten, D. Further studies on the properties of hepatic glutathione-insulin transhydrogenase. J. Biol. Chem. 238 (1963) 1006–1011. [PMID: 14031343] 2.  Kohnert, K.-D., Hahn, H.-J., Zühlke, H., Schmidt, S. and Fiedler, H. Breakdown of exogenous insulin by Langerhans islets of the pancreas in vitro. Biochim. Biophys. Acta 338 (1974) 68–77.
[EC 1.8.4.2 created 1965]