ExplorEnz: EC 2.1.1.346

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2.1.1.346

Accepted name:

U6 snRNA m⁶A methyltransferase

Reaction:

S-adenosyl-L-methionine + adenine in U6 snRNA = S-adenosyl-L-homocysteine + N⁶-methyladenine in U6 snRNA

Other name(s):

METTL16 (gene name)

Systematic name:

S-adenosyl-L-methionine:adenine in U6 snRNA methyltransferase

Comments:

This enzyme, found in vertebrates, methylates a specific adenine in a hairpin structure of snRNA. The effects of the binding of the methyltransferase to its substrate is important for the regulation of the activity of an isoform of EC 2.5.1.6, methionine adenosyltransferase, that produces S-adenosyl-L-methionine [1,2]. The enzyme also binds (and maybe methylates) the lncRNAs XIST and MALAT1 as well as a number of pre-mRNAs at specific positions often found in the intronic regions [2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Pendleton, K.E., Chen, B., Liu, K., Hunter, O.V., Xie, Y., Tu, B.P. and Conrad, N.K. The U6 snRNA m⁶A methyltransferase METTL16 regulates SAM synthetase intron retention. Cell 169 (2017) 824–835.e14. [DOI] [PMID: 28525753]
2.	Warda, A.S., Kretschmer, J., Hackert, P., Lenz, C., Urlaub, H., Hobartner, C., Sloan, K.E. and Bohnsack, M.T. Human METTL16 is a N⁶-methyladenosine (m⁶A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 18 (2017) 2004–2014. [DOI] [PMID: 29051200]

[EC 2.1.1.346 created 2018]