ExplorEnz: EC 2.4.1.357

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2.4.1.357

Accepted name:

phlorizin synthase

Reaction:

UDP-α-D-glucose + phloretin = UDP + phlorizin

For diagram of phloretin biosynthesis, click here

Glossary:

phloretin = 3-(4-hydroxyphenyl)-1-(2,4,6-trihydroxyphenyl)propan-1-one
phlorizin = 3-(4-hydroxyphenyl)-1-[2-(β-D-glucopyranosyloxy)-4,6-dihydroxyphenyl]propan-1-one

Other name(s):

MdPGT₁: P2’GT

Systematic name:

UDP-α-D-glucose:phloretin 2′-O-D-glucosyltransferase

Comments:

Isolated from Malus X domestica (apple). Phlorizin inhibits sodium-linked glucose transporters. It gives the characteristic flavour of apples and cider.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Jugdé, H., Nguy, D., Moller, I., Cooney, J.M. and Atkinson, R.G. Isolation and characterization of a novel glycosyltransferase that converts phloretin to phlorizin, a potent antioxidant in apple. FEBS J. 275 (2008) 3804–3814. [DOI] [PMID: 18573104]
2.	Yahyaa, M., Davidovich-Rikanati, R., Eyal, Y., Sheachter, A., Marzouk, S., Lewinsohn, E. and Ibdah, M. Identification and characterization of UDP-glucose:Phloretin 4′-O-glycosyltransferase from Malus x domestica Borkh. Phytochemistry 130 (2016) 47–55. [DOI] [PMID: 27316677]

[EC 2.4.1.357 created 2018]