| EC |
2.5.1.143 |
| Accepted name: |
pyridinium-3,5-biscarboxylic acid mononucleotide synthase |
| Reaction: |
deamido-NAD+ + hydrogencarbonate = AMP + pyridinium-3,5-biscarboxylate mononucleotide |
| Other name(s): |
LarB; P2CMN synthase; nicotinic acid adenine dinucleotide carboxylase/hydrolase; NaAD carboxylase/hydrolase |
| Systematic name: |
deamido-NAD+:hydrogencarbonate nicotinate-β-D-ribonucleotidyltransferase |
| Comments: |
This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor. It carboxylates the pyridinium ring of deamido-NAD+ and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5-biscarboxylic acid mononucleotide (P2CMN). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Desguin, B., Soumillion, P., Hols, P. and Hausinger, R.P. Nickel-pincer cofactor biosynthesis involves LarB-catalyzed pyridinium carboxylation and LarE-dependent sacrificial sulfur insertion. Proc. Natl. Acad. Sci. USA 113 (2016) 5598–5603. [DOI] [PMID: 27114550] |
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| [EC 2.5.1.143 created 2018] |
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