The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 2.7.1.227     
Accepted name: inositol phosphorylceramide synthase
Reaction: 1-phosphatidyl-1D-myo-inositol + a very-long-chain (2′R)-2′-hydroxyphytoceramide = 1,2-diacyl-sn-glycerol + a very-long-chain inositol phospho-(2′R)-2′-hydroxyphytoceramide
Glossary: a very-long-chain inositol phospho-(2′R)-2′-hydroxyphytoceramide = a very-long-chain inositol phospho-α-hydroxyphytoceramide = IPC
Other name(s): AUR1 (gene name); KEI1 (gene name)
Systematic name: 1-phosphatidyl-1D-myo-inositol:(2′R)-2′-hydroxy-phytoceramide phosphoinositoltransferase
Comments: The enzyme, characterized from yeast, attaches a phosphoinositol headgroup to α-hydroxyphytoceramides, generating a very-long-chain inositol phospho-α hydroxyphytoceramide (IPC), the simplest of the three complex sphingolipids produced by yeast.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Nagiec, M.M., Nagiec, E.E., Baltisberger, J.A., Wells, G.B., Lester, R.L. and Dickson, R.C. Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene. J. Biol. Chem. 272 (1997) 9809–9817. [PMID: 9092515]
2.  Levine, T.P., Wiggins, C.A. and Munro, S. Inositol phosphorylceramide synthase is located in the Golgi apparatus of Saccharomyces cerevisiae. Mol. Biol. Cell 11 (2000) 2267–2281. [PMID: 10888667]
3.  Sato, K., Noda, Y. and Yoda, K. Kei1: a novel subunit of inositolphosphorylceramide synthase, essential for its enzyme activity and Golgi localization. Mol. Biol. Cell 20 (2009) 4444–4457. [PMID: 19726565]
[EC 2.7.1.227 created 2019]
 
 


Data © 2001–2020 IUBMB
Web site © 2005–2020 Andrew McDonald