ExplorEnz: EC 2.7.1.95

2.7.1.95

Accepted name:

kanamycin kinase

Reaction:

ATP + kanamycin = ADP + kanamycin 3′-phosphate

Glossary:

kanamycin

Other name(s):

neomycin-kanamycin phosphotransferase;

Systematic name:

ATP:kanamycin 3′-O-phosphotransferase

Comments:

Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. An enzyme from Pseudomonas aeruginosa also acts on butirosin.

References:

1.	Doi, O., Ogura, M., Tanaka, N. and Umezawa, H. Inactivation of kanamycin, neomycin, and streptomycin by enzymes obtained in cells of Pseudomonas aeruginosa. Appl. Microbiol. 16 (1968) 1276–1281. [PMID: 4970990]
2.	Dolin, M.I. The Streptococcus faecalis oxidases for reduced diphosphopyridine nucleotide. III. Isolation and properties of a flavin peroxidase for reduced diphosphopyridine nucleotide. J. Biol. Chem. 225 (1957) 557–573. [PMID: 13416259]

[EC 2.7.1.95 created 1976]