EC	2.7.11.26
Accepted name:	tau-protein kinase
Reaction:	ATP + [tau-protein] = ADP + O-phospho-[tau-protein]
Other name(s):	ATP:tau-protein O-hosphotransferase; brain protein kinase PK40erk; cdk5/p20; CDK5/p23; glycogen synthase kinase-3β; GSK; protein tau kinase; STK31; tau kinase; [tau-protein] kinase; tau-protein kinase I; tau-protein kinase II; tau-tubulin kinase; TPK; TPK I; TPK II; TTK
Systematic name:	ATP:[tau-protein] O-phosphotransferase
Comments:	Activated by tubulin. Involved in the formation of paired helical filaments, which are the main fibrous component of all fibrillary lesions in brain and are associated with Alzheimer’s disease.
References:	1.  Ishiguro, K., Ihara, Y., Uchida, T. and Imahori, K. A novel tubulin-dependent protein kinase forming a paired helical filament epitope on tau. J. Biochem. (Tokyo) 104 (1988) 319–321. [PMID: 2467901] 2.  Lund, E.T., McKenna, R., Evans, D.B., Sharma, S.K. and Mathews, W.R. Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry. J. Neurochem. 76 (2001) 1221–1232. [PMID: 11181841] 3.  Michel, G., Mercken, M., Murayama, M., Noguchi, K., Ishiguro, K., Imahori, K. and Takashima, A. Characterization of tau phosphorylation in glycogen synthase kinase-3β and cyclin dependent kinase-5 activator (p23) transfected cells. Biochim. Biophys. Acta 1380 (1998) 177–182. [PMID: 9565682] 4.  Aoki, M., Iwamoto-Sugai, M., Sugiura, I., Sasaki, C., Hasegawa, T., Okumura, C., Sugio, S., Kohno, T. and Matsuzaki, T. Expression, purification and crystallization of human tau-protein kinase I/glycogen synthase kinase-3beta. Acta Crystallogr. D Biol. Crystallogr. 56 (2000) 1464–1465. [PMID: 11053853]
[EC 2.7.11.26 created 1990 as EC 2.7.1.135, transferred 2005 to EC 2.7.11.27]