ExplorEnz: EC 2.7.4.23

2.7.4.23

Accepted name:

ribose 1,5-bisphosphate phosphokinase

Reaction:

ATP + α-D-ribose 1,5-bisphosphate = ADP + 5-phospho-α-D-ribose 1-diphosphate

Glossary:

5-phospho-α-D-ribose 1-diphosphate = PRPP

Other name(s):

ribose 1,5-bisphosphokinase; PhnN; ATP:ribose-1,5-bisphosphate phosphotransferase

Systematic name:

ATP:α-D-ribose-1,5-bisphosphate phosphotransferase

Comments:

This enzyme, found in NAD supression mutants of Escherichia coli, synthesizes 5-phospho-α-D-ribose 1-diphosphate (PRPP) without the participation of EC 2.7.6.1, ribose-phosphate diphosphokinase. Ribose, ribose 1-phosphate and ribose 5-phosphate are not substrates, and GTP cannot act as a phosphate donor.

References:

Hove-Jensen, B., Rosenkrantz, T.J., Haldimann, A. and Wanner, B.L. Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways. J. Bacteriol. 185 (2003) 2793–2801. [PMID: 12700258]

[EC 2.7.4.23 created 2006]