EC	3.1.2.22
Accepted name:	palmitoyl[protein] hydrolase
Reaction:	palmitoyl[protein] + H2O = palmitate + protein
Other name(s):	palmitoyl-protein thioesterase; palmitoyl-(protein) hydrolase
Systematic name:	palmitoyl[protein] hydrolase
Comments:	Specific for long-chain thioesters of fatty acids. Hydrolyses fatty acids from S-acylated cysteine residues in proteins, palmitoyl cysteine and palmitoyl-CoA.
References:	1.  Camp, L.A., Hofmann, S.L. Assay and isolation of palmitoyl-protein thioesterase from bovine brain using palmitoylated H-Ras as substrate. Methods Enzymol. 250 (1995) 336–347. [PMID: 7651163] 2.  Schriner, J.E., Yi, W., Hofmann, S.L. cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis. Genomics 34 (1996) 317–322. [PMID: 8786130] 3.  Verkruyse, L.A., Hofmann, S.L. Lysosomal targeting of palmitoyl-protein thioesterase. J. Biol. Chem. 271 (1996) 15831–15836. [PMID: 8663305]
[EC 3.1.2.22 created 1999]