| EC |
3.1.3.67 |
| Accepted name: |
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase |
| Reaction: |
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate |
| Glossary: |
inositol 1,4,5-trisphosphate = Ins(1,4,5)P3
inositol 1,3,4,5-tetrakisphosphate = Ins(1,3,4,5)P4
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
| Other name(s): |
PTEN (gene name); MMAC1 (gene name); phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase |
| Systematic name: |
1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase |
| Comments: |
Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3 |
| References: |
| 1. |
Kabuyama, Y., Nakatsu, N., Homma, Y., Fukui, Y. Purification and characterization of phosphatidyl inositol-3,4,5-trisphosphate phosphatase in bovine thymus. Eur. J. Biochem. 238 (1996) 350–356. [PMID: 8681945] |
| 2. |
Maehama, T. and Dixon, J.E. The tumor suppressor, PTEN /MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 273 (1998) 13375–13378. [PMID: 9593664] |
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| [EC 3.1.3.67 created 1999, modified 2002] |
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