| EC |
3.4.23.42 |
| Accepted name: |
thermopsin |
| Reaction: |
Similar in specificity to pepsin A preferring bulky hydrophobic amino acids in P1 and P1′ |
| Comments: |
From the thermophilic archaeon Sulfolobus acidocaldarius. Maximally active at pH 2 and 90 °C. Weakly inhibited by pepstatin but shows no sequence similarity to pepsin. Type example of peptidase family A5. |
| References: |
| 1. |
Lin, X. and Tang, J. Thermopsin. Methods Enzymol. 248 (1995) 156–168. [PMID: 7674919] |
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| [EC 3.4.23.42 created 1992 as EC 3.4.99.43, transferred 2000 to EC 3.4.23.42] |
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