| EC |
3.5.1.131 |
| Accepted name: |
1-carboxybiuret hydrolase |
| Reaction: |
1-carboxybiuret + H2O = urea-1,3-dicarboxylate + NH3 |
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For diagram of atrazine catabolism, click here |
| Glossary: |
carboxybiuret = carbamoylcarbamoylcarbamic acid |
| Other name(s): |
atzEG (gene names) |
| Systematic name: |
1-carboxybiuret amidohydrolase |
| Comments: |
The enzyme, characterized from the bacterium Pseudomonas sp. ADP, participates in the degradation of cyanuric acid, an intermediate in the degradation of s-triazine herbicides such as atrazine [2-chloro-4-(ethylamino)-6-(isopropylamino)-1,3,5-triazine]. The enzyme is a heterotetramer composed of a catalytic subunit (AtzE) and an accessory subunit (AtzG) that stabilizes the complex. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Esquirol, L., Peat, T.S., Wilding, M., Liu, J.W., French, N.G., Hartley, C.J., Onagi, H., Nebl, T., Easton, C.J., Newman, J. and Scott, C. An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme. J. Biol. Chem. 293 (2018) 7880–7891. [DOI] [PMID: 29523689] |
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| [EC 3.5.1.131 created 2019] |
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