ExplorEnz: EC 3.5.2.2

3.5.2.2

Accepted name:

dihydropyrimidinase

Reaction:

5,6-dihydrouracil + H₂O = 3-ureidopropanoate

Other name(s):

hydantoinase; hydropyrimidine hydrase; hydantoin peptidase; pyrimidine hydrase; D-hydantoinase

Systematic name:

5,6-dihydropyrimidine amidohydrolase

Comments:

Also acts on dihydrothymine and hydantoin.

References:

1.	Brooks, K.P., Jones, E.A., Kim, B.-D. and Sander, E.G. Bovine liver dihydropyrimidine amidohydrolase: purification, properties, and characterization as a zinc metalloenzyme. Arch. Biochem. Biophys. 226 (1983) 469–483. [PMID: 6639068]
2.	Eadie, G.S., Bernheim, F. and Bernheim, J.L.C. Metabolism of cytosine, thymidine, uracil and barbituric acid by bacterial enzymes. J. Biol. Chem. 181 (1949) 449–458. [PMID: 15393763]

[EC 3.5.2.2 created 1961]