ExplorEnz: EC 3.5.3.26

3.5.3.26

Accepted name:

(S)-ureidoglycine aminohydrolase

Reaction:

(S)-2-ureidoglycine + H₂O = (S)-ureidoglycolate + NH₃

Other name(s):

UGlyAH; UGHY; ylbA (gene name)

Systematic name:

(S)-ureidoglycine aminohydrolase

Comments:

Binds Mn²⁺. This enzyme, found in plants and bacteria, is part of the ureide pathway, which enables the recycling of the nitrogen in purine compounds. In plants it is localized in the endoplasmic reticulum.

References:

1.	Serventi, F., Ramazzina, I., Lamberto, I., Puggioni, V., Gatti, R. and Percudani, R. Chemical basis of nitrogen recovery through the ureide pathway: formation and hydrolysis of S-ureidoglycine in plants and bacteria. ACS Chem. Biol. 5 (2010) 203–214. [PMID: 20038185]
2.	Werner, A.K., Romeis, T. and Witte, C.P. Ureide catabolism in Arabidopsis thaliana and Escherichia coli. Nat. Chem. Biol. 6 (2010) 19–21. [PMID: 19935661]
3.	Shin, I., Percudani, R. and Rhee, S. Structural and functional insights into (S)-ureidoglycine aminohydrolase, key enzyme of purine catabolism in Arabidopsis thaliana. J. Biol. Chem. 287 (2012) 18796–18805. [PMID: 22493446]

[EC 3.5.3.26 created 2013]