EC |
3.6.1.61 |
Accepted name: |
diadenosine hexaphosphate hydrolase (ATP-forming) |
Reaction: |
(1) P1,P6-bis(5′-adenosyl)hexaphosphate + H2O = 2 ATP
(2) P1,P5-bis(5′-adenosyl)pentaphosphate + H2O = ATP + ADP
(3) P1,P4-bis(5′-adenosyl)tetraphosphate + H2O = ATP + AMP
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Other name(s): |
Ndx1 |
Systematic name: |
P1,P6-bis(5′-adenosyl)hexaphosphate nucleotidohydrolase (ATP-forming) |
Comments: |
The enzyme requires the presence of the divalent cations (Mn2+, Mg2+, Zn2+, and Co2+). It hydrolyses P1,P4-bis(5-guanosyl) tetraphosphate very slowly [cf. EC 3.6.1.17, bis(5-nucleosyl)-tetraphosphatase (asymmetrical)]. |
References: |
1. |
Iwai, T., Kuramitsu, S. and Masui, R. The Nudix hydrolase Ndx1 from Thermus thermophilus HB8 is a diadenosine hexaphosphate hydrolase with a novel activity. J. Biol. Chem. 279 (2004) 21732–21739. [PMID: 15024014] |
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[EC 3.6.1.61 created 2012] |
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