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Your query returned 1 entry. 
Printable version
| EC | 3.6.1.71 | ||||
| Accepted name: | adenosine-5′-diphospho-5′-[DNA] diphosphatase | ||||
| Reaction: | (1) adenosine-5′-diphospho-5′-[DNA] + H2O = AMP + phospho-5′-[DNA] (2) adenosine-5′-diphospho-5′-(ribonucleotide)-[DNA] + H2O = AMP + 5′-phospho-(ribonucleotide)-[DNA] |
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| Other name(s): | aprataxin; 5′-App5′-DNA adenylate hydrolase; APTX (gene name); HNT3 (gene name) | ||||
| Systematic name: | adenosine-5′-diphospho-5′-[DNA] hydrolase (adenosine 5′-phosphate-forming) | ||||
| Comments: | Aprataxin is a DNA-binding protein involved in different types of DNA break repair. The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5′-phosphate DNA terminus. It also acts when the adenylate is covalently linked to the 5′-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, ribonuclease H, an enzyme that cleaves RNA-DNA hybrids on the 5′ side of the ribonucleotide found in the 5′-RNA-DNA-3′ junction. Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5′-phosphate terminus that can be efficiently rejoined. The enzyme also possesses the activities of EC 3.6.1.70, guanosine-5′-diphospho-5′-[DNA] diphosphatase, and EC 3.6.1.72, DNA-3′-diphospho-5′-guanosine diphosphatase. | ||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||
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