| EC |
4.1.1.22 |
| Accepted name: |
histidine decarboxylase |
| Reaction: |
L-histidine = histamine + CO2 |
| Other name(s): |
L-histidine decarboxylase; L-histidine carboxy-lyase |
| Systematic name: |
L-histidine carboxy-lyase (histamine-forming) |
| Comments: |
The enzyme from animal tissues contains a pyridoxal 5′-phosphate cofactor. The bacterial enzyme contains a tightly-bound pyruvoyl cofactor. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9024-61-7 |
| References: |
| 1. |
Epps, H.M.R. Studies on bacterial amino-acid decarboxylases. 4. l(–)-Histidine decarboxylase from Cl. welchii type A. Biochem. J. 39 (1945) 42–46. [PMID: 16747851] |
| 2. |
Riley, W.O. and Snell, E.E. Histidine decarboxylase of Lactobacillus 30a. IV. The presence of covalently bound pyruvate as the prosthetic group. Biochemistry 7 (1968) 3520–3528. [PMID: 5681461] |
| 3. |
Rosenthaler, J., Guirard, B.M., Chang, G.W. and Snell, E.E. Purification and properties of histidine decarboxylase from Lactobacillus 30a. Proc. Natl. Acad. Sci. USA 54 (1965) 152–158. [DOI] [PMID: 5216347] |
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| [EC 4.1.1.22 created 1961] |
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