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Your query returned 1 entry. Printable version
EC | 4.1.99.25 | ||||||||
Accepted name: | L-tryptophan isonitrile synthase | ||||||||
Reaction: | L-tryptophan + D-ribulose 5-phosphate = (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate + hydroxyacetone + formaldehyde + phosphate + H2O | ||||||||
For diagram of tryptophan isonitrile biosynthesis, click here | |||||||||
Glossary: | (2S)-3-(1H-indol-3-yl)-2-isocyanopropanoate = L-tryptophan isonitrile hydroxyacetone = 1-hydroxypropan-2-one |
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Other name(s): | isnA (gene name); ambI1 (gene name); well1 (gene name) | ||||||||
Systematic name: | L-tryptophan:D-ribulose-5-phosphate lyase (isonitrile-forming) | ||||||||
Comments: | The enzymes from cyanobacteria that belong to the Nostocales order participate in the biosynthesis of hapalindole-type alkaloids. According to the proposed mechanism, the enzyme forms an imine intermediate composed of linked L-tryptophan and D-ribulose 5-phosphate, followed by loss of the phosphate group and formation of a β-keto imine and keto-enol tautomerization. This is followed by a C-C bond cleavage, the release of hydroxyacetone, and a retro aldol type reaction that releases formaldehyde and forms the final product [3]. cf. EC 4.1.99.24, L-tyrosine isonitrile synthase. | ||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||
References: |
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