The Enzyme Database

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EC 4.2.1.139     
Accepted name: medicarpin synthase
Reaction: 4′-methoxyisoflavan-2′,4,7-triol = (–)-medicarpin + H2O
For diagram of medicarpin and formononetin derivatives biosynthesis, click here
Glossary: (–)-medicarpin = (6aR,11aR)-9-methoxy-6a,11a-dihydro-6H-[1]benzofuro[3,2-c]chromen-3-ol
Other name(s): medicarpan synthase; 7,2′-dihydroxy-4′-methoxyisoflavanol dehydratase; 2′,7-dihydroxy-4′-methoxyisoflavanol dehydratase; DMI dehydratase; DMID
Systematic name: 4′-methoxyisoflavan-2′,4,7-triol hydro-lyase [(–)-medicarpin-forming]
Comments: Isolated from the plant Medicago sativa (alfalfa). Catalyses the final step in the biosynthesis of medicarpin, the main pterocarpan phytoalexin in alfalfa.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Guo, L., Dixon, R.A. and Paiva, N.L. The ’pterocarpan synthase’ of alfalfa: association and co-induction of vestitone reductase and 7,2′-dihydroxy-4′-methoxy-isoflavanol (DMI) dehydratase, the two final enzymes in medicarpin biosynthesis. FEBS Lett. 356 (1994) 221–225. [PMID: 7805842]
2.  Guo, L., Dixon, R.A. and Paiva, N.L. Conversion of vestitone to medicarpin in alfalfa (Medicago sativa L.) is catalyzed by two independent enzymes. Identification, purification, and characterization of vestitone reductase and 7,2′-dihydroxy-4′-methoxyisoflavanol dehydratase. J. Biol. Chem. 269 (1994) 22372–22378. [PMID: 8071365]
[EC 4.2.1.139 created 2013]
 
 


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