ExplorEnz: EC 4.2.1.149

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4.2.1.149

Accepted name:

crotonobetainyl-CoA hydratase

Reaction:

L-carnitinyl-CoA = (E)-4-(trimethylammonio)but-2-enoyl-CoA + H₂O

Glossary:

L-carnitinyl-CoA = (3R)-3-hydroxy-4-(trimethylammonio)butanoyl-CoA
(E)-4-(trimethylammonio)but-2-enoyl-CoA = crotonobetainyl-CoA

Other name(s):

CaiD; L-carnityl-CoA dehydratase

Systematic name:

L-carnitinyl-CoA hydro-lyase [(E)-4-(trimethylammonio)but-2-enoyl-CoA-forming]

Comments:

The enzyme is also able to use crotonyl-CoA as substrate, with low efficiency [2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Engemann, C., Elssner, T. and Kleber, H.P. Biotransformation of crotonobetaine to L-(–)-carnitine in Proteus sp. Arch. Microbiol. 175 (2001) 353–359. [PMID: 11409545]
2.	Elssner, T., Engemann, C., Baumgart, K. and Kleber, H.P. Involvement of coenzyme A esters and two new enzymes, an enoyl-CoA hydratase and a CoA-transferase, in the hydration of crotonobetaine to L-carnitine by Escherichia coli. Biochemistry 40 (2001) 11140–11148. [DOI] [PMID: 11551212]
3.	Engemann, C., Elssner, T., Pfeifer, S., Krumbholz, C., Maier, T. and Kleber, H.P. Identification and functional characterisation of genes and corresponding enzymes involved in carnitine metabolism of Proteus sp. Arch. Microbiol. 183 (2005) 176–189. [DOI] [PMID: 15731894]

[EC 4.2.1.149 created 2014]