| EC |
4.2.3.155 |
| Accepted name: |
2-epi-valiolone synthase |
| Reaction: |
D-sedoheptulose 7-phosphate = 2-epi-valiolone + phosphate |
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For diagram of valiolone biosynthesis, click here |
| Glossary: |
2-epi-valiolone = (2S,3S,4S,5S)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohexan-1-one |
| Systematic name: |
D-sedoheptulose-7-phosphate phosphate-lyase (cyclizing; 2-epi-valiolone-forming) |
| Comments: |
The enzyme, characterized from the bacteria Actinosynnema mirum and Stigmatella aurantiaca DW4/3-1, produces 2-epi-valiolone, which is believed to function as a precursor in aminocyclitol biosynthesis. It requires a divalent metal ion (Zn2+ or Co2+) and an NAD+ cofactor, which is transiently reduced during the reaction. cf. EC 4.2.3.152, 2-epi-5-epi-valiolone synthase and EC 4.2.3.154, demethyl-4-deoxygadusol synthase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Asamizu, S., Xie, P., Brumsted, C.J., Flatt, P.M. and Mahmud, T. Evolutionary divergence of sedoheptulose 7-phosphate cyclases leads to several distinct cyclic products. J. Am. Chem. Soc. 134 (2012) 12219–12229. [DOI] [PMID: 22741921] |
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| [EC 4.2.3.155 created 2016] |
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