The Enzyme Database

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Accepted name: hydroxysqualene synthase
Reaction: presqualene diphosphate + H2O = hydroxysqualene + diphosphate
For diagram of botryococcus braunii BOT22 squalene and botrycoccene biosynthesis, click here
Glossary: presqualene = {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(2E,6E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropan-1-yl}methyl
hydroxysqualene = (6E,10E,12R,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaen-12-ol
Other name(s): hpnC (gene name)
Systematic name: presqualene diphosphate diphosphate-lyase (adding water; hydroxyasqualene-forming)
Comments: This enzyme, isolated from the bacteria Rhodopseudomonas palustris and Zymomonas mobilis, participates, along with EC, presqualene diphosphate synthase, and EC, hydroxysqualene dehydroxylase, in the conversion of all-trans-farnesyl diphosphate to squalene. Eukaryotes achieve the same goal in a single step, catalysed by EC, squalene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Pan, J.J., Solbiati, J.O., Ramamoorthy, G., Hillerich, B.S., Seidel, R.D., Cronan, J.E., Almo, S.C. and Poulter, C.D. Biosynthesis of squalene from farnesyl diphosphate in bacteria: three steps catalyzed by three enzymes. ACS Cent. Sci. 1 (2015) 77–82. [DOI] [PMID: 26258173]
[EC created 2016]

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