| EC |
4.2.3.162 |
| Accepted name: |
(–)-α-amorphene synthase |
| Reaction: |
(2E,6E)-farnesyl diphosphate = (–)-α-amorphene + diphosphate |
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For diagram of cadinane sesquiterpenoid biosynthesis, click here |
| Glossary: |
(–)-α-amorphene = (1S,4aR,8aS)-4,7-dimethyl-1-(propan-2-yl)-1,2,4a,5,6,8a-hexahydronaphthalene |
| Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (–)-α-amorphene-forming] |
| Comments: |
The enzyme, found in the bacterium Streptomyces viridochromogenes, is specific for (2E,6E)-farnesyl diphosphate and produces only (–)-α-amorphene. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Rabe, P. and Dickschat, J.S. Rapid chemical characterization of bacterial terpene synthases. Angew. Chem. Int. Ed. Engl. 52 (2013) 1810–1812. [DOI] [PMID: 23307484] |
| 2. |
Rinkel, J., Rabe, P., Garbeva, P. and Dickschat, J.S. Lessons from 1,3-hydride shifts in sesquiterpene cyclizations. Angew. Chem. Int. Ed. Engl. 55 (2016) 13593–13596. [DOI] [PMID: 27666571] |
| 3. |
Rabe, P., Schmitz, T. and Dickschat, J.S. Mechanistic investigations on six bacterial terpene cyclases. Beilstein J. Org. Chem. 12 (2016) 1839–1850. [DOI] [PMID: 27829890] |
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| [EC 4.2.3.162 created 2017] |
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