EC |
4.2.3.201 |
Accepted name: |
hydropyrene synthase |
Reaction: |
geranylgeranyl diphosphate = hydropyrene + diphosphate |
|
For mechanism, click here and for diagram of miscellaneous diterpenoid biosynthesis, click here |
Glossary: |
hydropyrene = (1R,3aR,3a1R,5aR,5a1S,8aS,10aS)-1,5a,8a-trimethyl-4-methylidenehexadecahydropyrene |
Other name(s): |
HpS |
Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, hydropyrene-forming) |
Comments: |
Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrenol, isoelisabethatriene and traces of other diterpenoids. cf. EC 4.2.3.202, hydropyrenol synthase, and EC 4.2.3.203, isoelisabethatriene synthase. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Rinkel, J., Rabe, P., Chen, X., Kollner, T.G., Chen, F. and Dickschat, J.S. Mechanisms of the diterpene cyclases β-pinacene synthase from Dictyostelium discoideum and hydropyrene synthase from Streptomyces clavuligerus. Chem. Eur. J. 23 (2017) 10501–10505. [PMID: 28696553] |
|
[EC 4.2.3.201 created 2019] |
|
|
|
|