The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

EC 4.2.3.202     
Accepted name: hydropyrenol synthase
Reaction: geranylgeranyl diphosphate + H2O = hydropyrenol + diphosphate
Glossary: hydropyrenol = (1R,3aR,3a1S,4S,5aR,5a1S,8aS,10aS)-1,4,5a,8a-tetramethylhexadecahydropyren-4-ol
Other name(s): HpS
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, hydropyrenol-forming)
Comments: Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrene, isoelisabethatriene and traces of other diterpenoids. cf. EC 4.2.3.201, hydropyrene synthase, and EC 4.2.3.203, isoelisabethatriene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Rinkel, J., Rabe, P., Chen, X., Kollner, T.G., Chen, F. and Dickschat, J.S. Mechanisms of the diterpene cyclases β-pinacene synthase from Dictyostelium discoideum and hydropyrene synthase from Streptomyces clavuligerus. Chem. Eur. J. 23 (2017) 10501–10505. [PMID: 28696553]
[EC 4.2.3.202 created 2019]
 
 


Data © 2001–2020 IUBMB
Web site © 2005–2020 Andrew McDonald