EC |
4.2.3.77 |
Accepted name: |
(+)-germacrene D synthase |
Reaction: |
(2E,6E)-farnesyl diphosphate = (+)-germacrene D + diphosphate |
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For diagram of germacrene sesquiterpenoid biosynthesis, click here |
Glossary: |
(+)-germacrene D = (1E,6E,8R)-1-methyl-5-methylidene-8-(propan-2-yl)cyclodeca-1,6-diene |
Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(+)-germacrene-D-forming] |
Comments: |
Requires Mg2+, Mn2+, Ni2+ or Co2+. The formation of (+)-germacrene D involves a 1,2-hydride shift whereas for (-)-germacrene D there is a 1,3-hydride shift (see EC 4.2.3.75). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Picaud, S., Olsson, M.E., Brodelius, M. and Brodelius, P.E. Cloning, expression, purification and characterization of recombinant (+)-germacrene D synthase from Zingiber officinale. Arch. Biochem. Biophys. 452 (2006) 17–28. [DOI] [PMID: 16839518] |
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[EC 4.2.3.77 created 2011] |
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