| EC |
4.2.3.8 |
| Accepted name: |
casbene synthase |
| Reaction: |
geranylgeranyl diphosphate = casbene + diphosphate |
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For diagram of cembrene and related diterpenoids, click here |
| Other name(s): |
casbene synthetase; geranylgeranyl-diphosphate diphosphate-lyase (cyclizing) |
| Systematic name: |
geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, casbene-forming) |
| Comments: |
The enzyme from castor bean (Ricinus communis) produces the antifungal diterpene casbene. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 69106-45-2 |
| References: |
| 1. |
Moesta, P. and West, C.A. Casbene synthetase: regulation of phytoalexin biosynthesis in Ricinus communis L. seedlings. Purification of casbene synthetase and regulation of its biosynthesis during elicitation. Arch. Biochem. Biophys. 238 (1985) 325–333. [DOI] [PMID: 3985625] |
| 2. |
Mau, C.J. and West, C.A. Cloning of casbene synthase cDNA: evidence for conserved structural features among terpenoid cyclases in plants. Proc. Natl. Acad. Sci. USA 91 (1994) 8497–8501. [DOI] [PMID: 8078910] |
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| [EC 4.2.3.8 created 1989 as EC 4.6.1.7, transferred 2000 to EC 4.2.3.8, modified 2024] |
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