ExplorEnz: EC 4.3.2.2

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4.3.2.2

Accepted name:

adenylosuccinate lyase

Reaction:

(1) N⁶-(1,2-dicarboxyethyl)AMP = fumarate + AMP
(2) (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate = fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide

For diagram of AMP and GMP biosynthesis, click here and for diagram of the late stages of purine biosynthesis, click here

Other name(s):

adenylosuccinase; succino AMP-lyase; 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase; 6-N-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

Systematic name:

N⁶-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming)

Comments:

Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5-aminoimidazole.

Links to other databases:

BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9027-81-0

References:

1.	Carter, C.E. and Cohen, L.H. The preparation and properties of adenylosuccinase and adenylosuccinic acid. J. Biol. Chem. 222 (1956) 17–30. [PMID: 13366975]

[EC 4.3.2.2 created 1961, modified 2000]