| EC |
5.3.3.1 |
| Accepted name: |
steroid Δ-isomerase |
| Reaction: |
a 3-oxo-Δ5-steroid = a 3-oxo-Δ4-steroid |
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For diagram of cholesterol catabolism (rings A, B and C), click here |
| Other name(s): |
hydroxysteroid isomerase; steroid isomerase; Δ5-ketosteroid isomerase; Δ5(or Δ4)-3-keto steroid isomerase; Δ5-steroid isomerase; 3-oxosteroid isomerase; Δ5-3-keto steroid isomerase; Δ5-3-oxosteroid isomerase |
| Systematic name: |
3-oxosteroid Δ5-Δ4-isomerase |
| Comments: |
This activity is catalysed by several distinct enzymes (cf. EC 1.1.3.6, cholesterol oxidase and EC 1.1.1.145, 3-hydroxy-5-steroid dehydrogenase). |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9031-36-1 |
| References: |
| 1. |
Ewald, W., Werbein, H. and Chaikoff, I.L. Evidence for the presence of 17-hydroxypregnenedione isomerase in beef adrenal cortex. Biochim. Biophys. Acta 111 (1965) 306–312. [DOI] [PMID: 5867327] |
| 2. |
Kawahara, F.S. and Talalay, P. Crystalline Δ5-3-ketosteroid isomerase. J. Biol. Chem. 235 (1960) PC1–PC2. [PMID: 14404954] |
| 3. |
Talalay, P. and Wang, V.S. Enzymic isomerization of Δ5-3-ketosteroids. Biochim. Biophys. Acta 18 (1955) 300–301. [PMID: 13276386] |
| 4. |
MacLachlan, J., Wotherspoon, A.T., Ansell, R.O. and Brooks, C.J. Cholesterol oxidase: sources, physical properties and analytical applications. J. Steroid Biochem. Mol. Biol. 72 (2000) 169–195. [DOI] [PMID: 10822008] |
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| [EC 5.3.3.1 created 1961] |
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