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Your query returned 1 entry. Printable version
EC | 6.3.2.40 | ||||||
Accepted name: | cyclopeptine synthase | ||||||
Reaction: | 2 ATP + S-adenosyl-L-methionine + anthranilate + L-phenylalanine = cyclopeptine + 2 AMP + 2 diphosphate + S-adenosyl-L-homocysteine | ||||||
For diagram of cyclopeptine, cyclopenine and viridicatin biosynthesis, click here | |||||||
Glossary: | cyclopeptine = (3S)-3-benzyl-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione 4′-methoxycyclopeptine = (3S)-3-(4-methoxybenzyl)-4-methyl-3,4-dihydro-1H-1,4-benzodiazepine-2,5-dione |
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Systematic name: | S-adenosyl-L-methionine:anthranilate:L-phenylalanine ligase (cyclopeptine-forming) | ||||||
Comments: | Cyclopeptine synthase is the key enzyme of benzodiazepine alkaloid biosynthesis in several fungi species. The enzyme is a non-ribosomal peptide synthase. It is also active with O-methyl-L-tyrosine forming 4′-methoxycyclopeptine. | ||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||
References: |
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