ExplorEnz: EC 7.4.2.3

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7.4.2.3

Accepted name:

mitochondrial protein-transporting ATPase

Reaction:

ATP + H₂O + mitochondrial-protein_{[side 1]} = ADP + phosphate + mitochondrial-protein_{[side 2]}

Systematic name:

ATP phosphohydrolase (mitochondrial protein-importing)

Comments:

A non-phosphorylated, non-ABC (ATP-binding cassette) ATPase involved in the transport of proteins or preproteins into mitochondria using the TIM protein complex. TIM is the protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Bomer, U., Meijer, M., Maarse, A.C., Honlinger, A., Dekker, P.J., Pfanner, N. and Rassow, J. Multiple interactions of components mediating preprotein translocation across the inner mitochondrial membrane. EMBO J. 16 (1997) 2205–2216. [DOI] [PMID: 9171336]
2.	Berthold, J., Bauer, M.F., Schneider, H.C., Klaus, C., Dietmeier, K., Neupert, W. and Brunner, M. The MIM complex mediates preprotein translocation across the mitochondrial inner membrane and couples it to the mt-Hsp70/ATP-driving system. Cell 81 (1995) 1085–1093. [DOI] [PMID: 7600576]
3.	Voos, W., Martin, H., Krimmer, T. and Pfanner, N. Mechanisms of protein translocation into mitochondria. Biochim. Biophys. Acta 1422 (1999) 235–254. [DOI] [PMID: 10548718]

[EC 7.4.2.3 created 2000 as EC 3.6.3.51, transferred 2018 to EC 7.4.2.3]