| EC |
4.1.3.22 |
| Accepted name: |
citramalate lyase |
| Reaction: |
(2S)-2-hydroxy-2-methylbutanedioate = acetate + pyruvate |
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For diagram of reaction, click here |
| Glossary: |
(+)-citramalate = (2S)-2-hydroxy-2-methylbutanedioate |
| Other name(s): |
citramalate pyruvate-lyase; citramalate synthase; citramalic-condensing enzyme; citramalate synthetase; citramalic synthase; (S)-citramalate lyase; (+)-citramalate pyruvate-lyase; citramalate pyruvate lyase; (3S)-citramalate pyruvate-lyase; (2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase |
| Systematic name: |
(2S)-2-hydroxy-2-methylbutanedioate pyruvate-lyase (acetate-forming) |
| Comments: |
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.11 (citramalate CoA-transferase) and EC 4.1.3.25 (citramalyl-CoA lyase). |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9027-93-4 |
| References: |
| 1. |
Barker, H.A. Citramalate lyase of Clostridium tetanomorphum. Arch. Mikrobiol. 59 (1967) 4–12. [PMID: 4301387] |
| 2. |
Dimroth, P., Buckel, W., Loyal, R. and Eggerer, H. Isolation and function of the subunits of citramalate lyase and formation of hybrids with the subunits of citrate lyase. Eur. J. Biochem. 80 (1977) 469–477. [DOI] [PMID: 923590] |
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| [EC 4.1.3.22 created 1972] |
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| EC |
4.2.1.34 |
| Accepted name: |
(S)-2-methylmalate dehydratase |
| Reaction: |
(S)-2-methylmalate = 2-methylfumarate + H2O |
| Other name(s): |
mesaconate hydratase; (+)-citramalate hydro-lyase; L-citramalate hydrolase; citramalate dehydratase; (+)-citramalic hydro-lyase; mesaconate mesaconase; mesaconase; (S)-2-methylmalate hydro-lyase |
| Systematic name: |
(S)-2-methylmalate hydro-lyase (2-methylfumarate-forming) |
| Comments: |
Also hydrates fumarate to (S)-malate. |
| Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, CAS registry number: 9027-94-5 |
| References: |
| 1. |
Blair, A.H. and Barker, H.A. Assay and purification of (+)-citramalate hydro-lyase components from Clostridium tetanomorphum. J. Biol. Chem. 241 (1966) 400–408. [PMID: 5903732] |
| 2. |
Wang, C.C. and Barker, H.A. Purification and properties of L-citramalate hydrolyase. J. Biol. Chem. 244 (1969) 2516–2526. [PMID: 5769987] |
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| [EC 4.2.1.34 created 1972] |
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