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Your query returned 2 entries. Printable version
EC | 4.2.1.79 | ||||
Accepted name: | 2-methylcitrate dehydratase | ||||
Reaction: | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate = (Z)-but-2-ene-1,2,3-tricarboxylate + H2O | ||||
Glossary: | (2S,3S)-2-methylcitrate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate cis-2-methylaconitate = (Z)-but-2-ene-1,2,3-tricarboxylate |
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Other name(s): | 2-methylcitrate hydro-lyase; PrpD; 2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase | ||||
Systematic name: | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase [(Z)-but-2-ene-1,2,3-tricarboxylate-forming] | ||||
Comments: | The enzyme is specific for (2S,3S)-methylcitrate, showing no activity with (2R,3S)-methylcitrate [2]. The enzyme can also use cis-aconitate as a substrate but more slowly [2]. Both this enzyme and EC 4.2.1.3, aconitate hydratase, are required to complete the isomerization of (2S,3S)-methylcitrate to (2R,3S)-2-methylisocitrate [2]. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 80891-26-5 | ||||
References: |
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EC | 4.2.1.117 | ||||
Accepted name: | 2-methylcitrate dehydratase (2-methyl-trans-aconitate forming) | ||||
Reaction: | (2S,3S)-2-methylcitrate = 2-methyl-trans-aconitate + H2O | ||||
Glossary: | (2S,3S)-2-methylcitrate = (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate 2-methyl-trans-aconitate = (2E)-but-2-ene-1,2,3-tricarboxylate |
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Systematic name: | (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate hydro-lyase (2-methyl-trans-aconitate-forming) | ||||
Comments: | Catalyses the dehydration of (2S,3S)-2-methylcitrate, forming the trans isomer of 2-methyl-aconitate (unlike EC 4.2.1.79, which forms only the cis isomer). Part of a propionate degradation pathway. The enzyme from Shewanella oneidensis can also accept citrate and cis-aconitate, but activity with (2S,3S)-2-methylcitrate was approximately 2.5-fold higher. 2-methylisocitrate and isocitrate were not substrates [1]. An iron-sulfur protein. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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