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Your query returned 5 entries. Printable version
EC | 2.7.1.153 | ||||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 3-kinase | ||||||||||
Reaction: | ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol = PtdIns 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
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Other name(s): | type I phosphoinositide 3-kinase | ||||||||||
Systematic name: | ATP:1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 3-phosphotransferase | ||||||||||
Comments: | This enzyme also catalyses the phosphorylation of PtdIns4P to PtdIns(3,4)P2, and of PtdIns to PtdIns3P. Four mammalian isoforms are known to exist. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 103843-30-7 | ||||||||||
References: |
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EC | 3.1.3.36 | ||||||||||
Accepted name: | phosphoinositide 5-phosphatase | ||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 1,4-bisphosphate = PtdIns(1,4)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 1,3,4-trisphosphate = PtdIns(1,3,4)P3 1-phosphatidyl-1D-myo-inositol 1,4,5-trisphosphate = PtdIns(1,4,5)P3 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 1,3,4,5-tetrakisphosphate = PtdIns(1,3,4,5)P4 |
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Other name(s): | type II inositol polyphosphate 5-phosphatase; triphosphoinositide phosphatase; IP3 phosphatase; PtdIns(4,5)P2 phosphatase; triphosphoinositide phosphomonoesterase; diphosphoinositide phosphatase; inositol 1,4,5-triphosphate 5-phosphomonoesterase; inositol triphosphate 5-phosphomonoesterase; phosphatidylinositol-bisphosphatase; phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase; phosphatidylinositol 4,5-bisphosphate phosphatase; polyphosphoinositol lipid 5-phosphatase; phosphatidyl-inositol-bisphosphate phosphatase | ||||||||||
Systematic name: | phosphatidyl-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | ||||||||||
Comments: | These enzymes can also remove the 5-phosphate from Ins(1,4,5)P3 and/or Ins(1,3,4,5)P4. They are a diverse family of enzymes, with differing abilities to catalyse two or more of the four reactions listed. They are thought to use inositol lipids rather than inositol phosphates as substrates in vivo. All of them can use either or both of PtdIns(4,5)P2 and PtdIns(3,4,5)P3 as substrates; this is the main property that distinguishes them from EC 3.1.3.56, inositol-polyphosphate 5-phosphatase. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9036-01-5 | ||||||||||
References: |
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EC | 3.1.3.67 | ||||||||||
Accepted name: | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase | ||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + phosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism (part 2), click here | |||||||||||
Glossary: | inositol 1,4,5-trisphosphate = Ins(1,4,5)P3 inositol 1,3,4,5-tetrakisphosphate = Ins(1,3,4,5)P4 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
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Other name(s): | PTEN; MMAC1; phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase | ||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase | ||||||||||
Comments: | Requires Mg2+. Does not dephosphorylate inositol 4,5-bisphosphate. This enzyme still works when the 2,3-bis(acyloxy)propyl group is removed, i.e., it hydrolyses Ins(1,3,4,5)P4 to Ins(1,4,5)P3 | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 210488-47-4 | ||||||||||
References: |
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EC | 3.1.3.78 | ||||||||||
Accepted name: | phosphatidylinositol-4,5-bisphosphate 4-phosphatase | ||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate | ||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3-phosphate = PtdIns3P 1-phosphatidyl-1D-myo-inositol 4-phosphate = PtdIns4P 1-phosphatidyl-1D-myo-inositol 5-phosphate = PtdIns5P 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate = PtdIns(3,5)P2 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = PtdIns(4,5)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 |
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Other name(s): | phosphatidylinositol-4,5-bisphosphate 4-phosphatase I; phosphatidylinositol-4,5-bisphosphate 4-phosphatase II; type I PtdIns-4,5-P2 4-Ptase; type II PtdIns-4,5-P2 4-Ptase; IpgD; PtdIns-4,5-P2 4-phosphatase type I; PtdIns-4,5-P2 4-phosphatase type II; type I phosphatidylinositol-4,5-bisphosphate 4-phosphatase; type 1 4-phosphatase | ||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate 4-phosphohydrolase | ||||||||||
Comments: | Two pathways exist in mammalian cells to degrade 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [PtdIns(4,5)P2] [2]. One is catalysed by this enzyme and the other by EC 3.1.3.36, phosphoinositide 5-phosphatase, where the product is PtdIns4P. The enzyme from human is specific for PtdIns(4,5)P2 as substrate, as it cannot use PtdIns(3,4,5)P3, PtdIns(3,4)P2, PtdIns(3,5)P2, PtdIns5P, PtdIns4P or PtdIns3P [2]. In humans, the enzyme is localized to late endosomal/lysosomal membranes [2]. It can control nuclear levels of PtdIns5P and thereby control p53-dependent apoptosis [3]. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||
References: |
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EC | 3.1.3.86 | ||||||||||
Accepted name: | phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase | ||||||||||
Reaction: | 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate | ||||||||||
For diagram of 1-phosphatidyl-myo-inositol metabolism, click here | |||||||||||
Glossary: | 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate = PtdIns(3,4)P2 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate = PtdIns(3,4,5)P3 1-phosphatidyl-1D-myo-inositol 1,3,4,5-trisphosphate = PtdIns(1,3,4,5)P4 |
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Other name(s): | SHIP1; SHIP2; SHIP; p150Ship | ||||||||||
Systematic name: | 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase | ||||||||||
Comments: | This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. The enzyme also shows activity toward (PtdIns(1,3,4,5)P4) [5]. The enzyme is involved in several signal transduction pathways in the immune system leading to an adverse range of effects. | ||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||
References: |
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