The Enzyme Database

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EC 2.7.1.188     
Accepted name: 2-epi-5-epi-valiolone 7-kinase
Reaction: ATP + 2-epi-5-epi-valiolone = ADP + 2-epi-5-epi-valiolone 7-phosphate
For diagram of valiolone biosynthesis, click here
Glossary: 2-epi-5-epi-valiolone = (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(hydroxymethyl)cyclohexan-1-one
Other name(s): AcbM
Systematic name: ATP:2-epi-5-epi-valiolone 7-phosphotransferase
Comments: The enzyme, characterized from the bacterium Actinoplanes sp. SE50/110, is involved in the biosynthesis of the oligosaccharide acarbose.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Zhang, C.S., Stratmann, A., Block, O., Bruckner, R., Podeschwa, M., Altenbach, H.J., Wehmeier, U.F. and Piepersberg, W. Biosynthesis of the C7-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway. J. Biol. Chem. 277 (2002) 22853–22862. [DOI] [PMID: 11937512]
[EC 2.7.1.188 created 2015]
 
 
EC 5.1.3.35     
Accepted name: 2-epi-5-epi-valiolone 7-phosphate 2-epimerase
Reaction: 2-epi-5-epi-valiolone 7-phosphate = 5-epi-valiolone 7-phosphate
For diagram of valiolone biosynthesis, click here
Glossary: 2-epi-5-epi-valiolone 7-phosphate = (2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(phosphonooxymethyl)cyclohexanone
5-epi-valiolone 7-phosphate = (2R,3S,4S,5R)-2,3,4,5-tetrahydroxy-5-(phosphonooxymethyl)cyclohexanone
Other name(s): AcbO
Systematic name: 2-epi-5-epi-valiolone-7-phosphate 2-epimerase
Comments: The enzyme, isolated from the bacterium Actinoplanes sp. SE 50/110, is involved in the biosynthesis of the α-glucosidase inhibitor acarbose.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Zhang, C.S., Podeschwa, M., Altenbach, H.J., Piepersberg, W. and Wehmeier, U.F. The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase. FEBS Lett. 540 (2003) 47–52. [DOI] [PMID: 12681481]
[EC 5.1.3.35 created 2015]
 
 


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