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Your query returned 1 entry. 
Printable version
| EC | 1.21.99.4 | ||||||||
| Accepted name: | thyroxine 5′-deiodinase | ||||||||
| Reaction: | 3,3′,5-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + reduced acceptor | ||||||||
| Glossary: | 3,3′,5-triiodo-L-thyronine = O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine L-thyroxine = O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine |
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| Other name(s): | diiodothyronine 5′-deiodinase [ambiguous]; iodothyronine 5′-deiodinase; iodothyronine outer ring monodeiodinase; type I iodothyronine deiodinase; type II iodothyronine deiodinase; thyroxine 5-deiodinase [misleading]; L-thyroxine iodohydrolase (reducing) | ||||||||
| Systematic name: | 3,3′,5-triiodo-L-thyronine,iodide:acceptor oxidoreductase (iodinating) | ||||||||
| Comments: | The enzyme activity has only been demonstrated in the direction of 5′-deiodination, which renders the thyroid hormone more active. The enzyme consists of type I and type II enzymes, both containing selenocysteine, but with different kinetics. For the type I enzyme the first reaction is a reductive deiodination converting the -Se-H group of the enzyme into an -Se-I group; the reductant then reconverts this into -Se-H, releasing iodide. | ||||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 70712-46-8 | ||||||||
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