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1.14.13.163

Accepted name:

6-hydroxy-3-succinoylpyridine 3-monooxygenase

Reaction:

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate + 2 NADH + 2 H⁺ + O₂ = 2,5-dihydroxypyridine + succinate semialdehyde + 2 NAD⁺ + H₂O

Glossary:

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate = 6-hydroxy-3-succinoyl-pyridine

Other name(s):

6-hydroxy-3-succinoylpyridine hydroxylase; hspA (gene name); hspB (gene name)

Systematic name:

4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing)

Comments:

The enzyme catalyses a reaction in the nicotine degradation pathway of Pseudomonas species. One of the enzymes from the soil bacterium Pseudomonas putida S16 contains an FAD cofactor [2].

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Tang, H., Wang, S., Ma, L., Meng, X., Deng, Z., Zhang, D., Ma, C. and Xu, P. A novel gene, encoding 6-hydroxy-3-succinoylpyridine hydroxylase, involved in nicotine degradation by Pseudomonas putida strain S16. Appl. Environ. Microbiol. 74 (2008) 1567–1574. [DOI] [PMID: 18203859]
2.	Tang, H., Yao, Y., Zhang, D., Meng, X., Wang, L., Yu, H., Ma, L. and Xu, P. A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida. J. Biol. Chem. 286 (2011) 39179–39187. [DOI] [PMID: 21949128]

[EC 1.14.13.163 created 2012]