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Your query returned 2 entries. Printable version
EC | 1.1.1.352 | ||||
Accepted name: | 5′-hydroxyaverantin dehydrogenase | ||||
Reaction: | (1) (1′S,5′S)-hydroxyaverantin + NAD+ = 5′-oxoaverantin + NADH + H+ (2) (1′S,5′R)-hydroxyaverantin + NAD+ = 5′-oxoaverantin + NADH + H+ |
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Glossary: | 5′-oxoaverantin = 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione |
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Other name(s): | HAVN dehydrogenase; adhA (gene name) | ||||
Systematic name: | (1′S,5′S)-hydroxyaverantin:NAD+ oxidoreductase | ||||
Comments: | Isolated from the aflatoxin-producing mold Aspergillus parasiticus [2]. Involved in aflatoxin biosynthesis. 5′-Oxoaverantin will spontaneously form averufin by intramolecular ketalisation. cf. EC 4.2.1.142, 5′-oxoaverantin cyclase. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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EC | 4.2.1.142 | ||||
Accepted name: | 5′-oxoaverantin cyclase | ||||
Reaction: | 5′-oxoaverantin = (1′S,5′S)-averufin + H2O | ||||
For diagram of aflatoxin biosynthesis (part 1), click here | |||||
Glossary: | 5′-oxoaverantin = 1,3,6,8-tetrahydroxy-2-[(1S)-1-hydroxy-5-oxohexyl]anthracene-9,10-dione averufin = 7,9,11-trihydroxy-2-methyl-3,4,5,6-tetrahydro-2,6-epoxy-2H-anthra[2,3-b]oxocin-8,13-dione |
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Other name(s): | OAVN cyclase; 5′-oxoaverantin hydro-lyase [(2′S,5′S)-averufin forming] | ||||
Systematic name: | 5′-oxoaverantin hydro-lyase [(1′S,5′S)-averufin-forming] | ||||
Comments: | Isolated from the aflatoxin-producing mold Aspergillus parasiticus. The enzyme also catalyses the conversion of versiconal to versicolorin B (EC 4.2.1.143, versicolorin B synthase). Involved in aflatoxin biosynthesis. | ||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||
References: |
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