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Your query returned 2 entries. Printable version
EC | 3.6.1.58 | ||||||||||||
Accepted name: | 8-oxo-dGDP phosphatase | ||||||||||||
Reaction: | (1) 8-oxo-dGDP + H2O = 8-oxo-dGMP + phosphate (2) 8-oxo-GDP + H2O = 8-oxo-GMP + phosphate |
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Glossary: | 8-oxo-dGDP = 8-oxo-7,8-dihydro-2′-deoxyguanosine 5′-diphosphate | ||||||||||||
Other name(s): | NUDT5; MTH3 (gene name); NUDT18 | ||||||||||||
Systematic name: | 8-oxo-dGDP phosphohydrolase | ||||||||||||
Comments: | The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase) [1,2]. Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13, ADP-ribose diphosphatase) [4]. The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate [6]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 3.6.1.69 | ||||||||||||
Accepted name: | 8-oxo-(d)GTP phosphatase | ||||||||||||
Reaction: | (1) 8-oxo-GTP + H2O = 8-oxo-GDP + phosphate (2) 8-oxo-dGTP + H2O = 8-oxo-dGDP + phosphate |
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Glossary: | 8-oxo-dGTP = 2′-deoxy-7,8-dihydro-8-oxoguanosine 5′-triphosphate | ||||||||||||
Other name(s): | mutT1 (gene name) | ||||||||||||
Systematic name: | 8-oxo-dGTP diphosphohydrolase | ||||||||||||
Comments: | The enzyme, characterized from the bacterium Mycobacterium tuberculosis, catalyses the hydrolysis of both 8-oxo-GTP and 8-oxo-dGTP, thereby preventing transcriptional and translational errors caused by oxidative damage. The enzyme is highly specific. Unlike EC 3.6.1.55, 8-oxo-dGTP diphosphatase, it removes only a single phosphate group. The nucleoside diphosphate products are hydrolysed further by EC 3.6.1.58, 8-oxo-dGDP phosphatase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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