EC |
1.1.1.342 |
Accepted name: |
CDP-paratose synthase |
Reaction: |
CDP-α-D-paratose + NADP+ = CDP-4-dehydro-3,6-dideoxy-α-D-glucose + NADPH + H+ |
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For diagram of CDP-abequose, CDP-ascarylose, CDP-paratose and CDP-tyrelose biosynthesis, click here |
Glossary: |
CDP-α-D-paratose = CDP-3,6-dideoxy-α-D-glucose = CDP-3,6-dideoxy-α-D-ribo-hexose |
Other name(s): |
rfbS (gene name) |
Systematic name: |
CDP-α-D-paratose:NADP+ 4-oxidoreductase |
Comments: |
The enzyme is involved in synthesis of paratose and tyvelose, unusual 3,6-dideoxyhexose sugars that form part of the O-antigen in the lipopolysaccharides of several enteric bacteria. Isolated from Salmonella enterica subsp. enterica serovar Typhi (Salmonella typhi). |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Verma, N. and Reeves, P. Identification and sequence of rfbS and rfbE, which determine antigenic specificity of group A and group D salmonellae. J. Bacteriol. 171 (1989) 5694–5701. [DOI] [PMID: 2793833] |
2. |
Hallis, T.M., Lei, Y., Que, N.L. and Liu, H. Mechanistic studies of the biosynthesis of paratose: purification and characterization of CDP-paratose synthase. Biochemistry 37 (1998) 4935–4945. [DOI] [PMID: 9538012] |
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[EC 1.1.1.342 created 2012] |
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EC |
5.1.3.10 |
Accepted name: |
CDP-paratose 2-epimerase |
Reaction: |
CDP-α-D-paratose = CDP-α-D-tyvelose |
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For diagram of CDP-abequose, CDP-ascarylose, CDP-paratose and CDP-tyrelose biosynthesis, click here |
Glossary: |
CDP-α-D-tyvelose = CDP-3,6-dideoxy-α-D-mannose = CDP-3,6-dideoxy-α-D-arabino-hexose
CDP-α-D-paratose = CDP-3,6-dideoxy-α-D-glucose = CDP-3,6-dideoxy-α-D-ribo-hexose |
Other name(s): |
CDP-paratose epimerase; cytidine diphosphoabequose epimerase; cytidine diphosphodideoxyglucose epimerase; cytidine diphosphoparatose epimerase; cytidine diphosphate paratose-2-epimerase; CDP-abequose epimerase (incorrect); CDP-D-abequose 2-epimerase (incorrect); CDP-tyvelose 2-epimerase, |
Systematic name: |
CDP-3,6-dideoxy-D-glucose 2-epimerase |
Comments: |
Requires NAD+. |
Links to other databases: |
BRENDA, EXPASY, GTD, KEGG, MetaCyc, PDB, CAS registry number: 37318-36-8 |
References: |
1. |
Matsuhashi, S. Enzymatic synthesis of cytidine diphosphate 3,6-dideoxyhexoses. II. Reversible 2-epimerization of cytidine diphosphate paratose. J. Biol. Chem. 241 (1966) 4275–4282. [PMID: 5924649] |
2. |
Liu, H.-W. and Thorson, J.S. Pathways and mechanisms in the biogenesis of novel deoxysugars by bacteria. Annu. Rev. Microbiol. 48 (1994) 223–256. [DOI] [PMID: 7826006] |
3. |
Koropatkin, N.M., Liu, H.W. and Holden, H.M. High resolution x-ray structure of tyvelose epimerase from Salmonella typhi. J. Biol. Chem. 278 (2003) 20874–20881. [DOI] [PMID: 12642575] |
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[EC 5.1.3.10 created 1972, modified 2005] |
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