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Your query returned 3 entries. Printable version
EC | 1.1.1.187 | ||||||||||||
Accepted name: | GDP-4-dehydro-D-rhamnose reductase | ||||||||||||
Reaction: | (1) GDP-α-D-rhamnose + NAD(P)+ = GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H+ (2) GDP-6-deoxy-α-D-talose + NAD(P)+ = GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H+ |
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For diagram of gdp-l-fucose and GDP-mannose biosynthesis, click here | |||||||||||||
Glossary: | GDP-α-D-rhamnose = GDP-6-deoxy-α-D-mannose GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose GDP-6-deoxy-α-D-talose = GDP-α-D-pneumose |
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Other name(s): | GDP-4-keto-6-deoxy-D-mannose reductase; GDP-4-keto-D-rhamnose reductase; guanosine diphosphate-4-keto-D-rhamnose reductase; GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase; GDP-6-deoxy-α-D-mannose:NAD(P)+ 4-oxidoreductase | ||||||||||||
Systematic name: | GDP-4-dehydro-α-D-rhamnose:NAD(P)+ 4-oxidoreductase | ||||||||||||
Comments: | The enzyme, which operates in the opposite direction to that shown, forms a mixture of GDP-α-D-rhamnose and its C-4 epimer, GDP-6-deoxy-α-D-talose. cf. EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase and EC 1.1.1.135, GDP-6-deoxy-D-talose 4-dehydrogenase. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 9075-56-3 | ||||||||||||
References: |
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EC | 1.1.1.281 | ||||||||||||
Accepted name: | GDP-4-dehydro-6-deoxy-D-mannose reductase | ||||||||||||
Reaction: | GDP-α-D-rhamnose + NAD(P)+ = GDP-4-dehydro-α-D-rhamnose + NAD(P)H + H+ | ||||||||||||
For diagram of gdp-l-fucose and GDP-mannose biosynthesis, click here | |||||||||||||
Glossary: | GDP-α-D-rhamnose = GDP-6-deoxy-α-D-mannose GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose |
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Other name(s): | GDP-4-keto-6-deoxy-D-mannose reductase [ambiguous]; GDP-6-deoxy-D-lyxo-4-hexulose reductase; Rmd; GDP-6-deoxy-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming); GDP-6-deoxy-α-D-mannose:NAD(P)+ 4-oxidoreductase (D-rhamnose-forming) | ||||||||||||
Systematic name: | GDP-α-D-rhamnose:NAD(P)+ 4-oxidoreductase | ||||||||||||
Comments: | This enzyme differs from EC 1.1.1.187, GDP-4-dehydro-D-rhamnose reductase, in that the only product formed is GDP-α-D-rhamnose. D-Rhamnose is a constituent of lipopolysaccharides of Gram-negative plant and human pathogenic bacteria. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB | ||||||||||||
References: |
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EC | 4.2.1.47 | ||||||||||||
Accepted name: | GDP-mannose 4,6-dehydratase | ||||||||||||
Reaction: | GDP-α-D-mannose = GDP-4-dehydro-α-D-rhamnose + H2O | ||||||||||||
For diagram of gdp-l-fucose and GDP-mannose biosynthesis, click here | |||||||||||||
Glossary: | GDP-4-dehydro-α-D-rhamnose = GDP-4-dehydro-6-deoxy-α-D-mannose | ||||||||||||
Other name(s): | guanosine 5′-diphosphate-D-mannose oxidoreductase; guanosine diphosphomannose oxidoreductase; guanosine diphosphomannose 4,6-dehydratase; GDP-D-mannose dehydratase; GDP-D-mannose 4,6-dehydratase; Gmd; GDP-mannose 4,6-hydro-lyase; GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming) | ||||||||||||
Systematic name: | GDP-α-D-mannose 4,6-hydro-lyase (GDP-4-dehydro-α-D-rhamnose-forming) | ||||||||||||
Comments: | The bacterial enzyme requires bound NAD+. This enzyme forms the first step in the biosynthesis of GDP-α-D-rhamnose and GDP-β-L-fucose. In Aneurinibacillus thermoaerophilus L420-91T, this enzyme acts as a bifunctional enzyme, catalysing the above reaction as well as the reaction catalysed by EC 1.1.1.281, GDP-4-dehydro-6-deoxy-D-mannose reductase [5]. Belongs to the short-chain dehydrogenase/reductase enzyme family, having homologous structures and a conserved catalytic triad of Lys, Tyr and Ser/Thr residues [6]. | ||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 37211-59-9 | ||||||||||||
References: |
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