The Enzyme Database

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EC 5.1.1.19     
Accepted name: O-ureido-serine racemase
Reaction: O-ureido-L-serine = O-ureido-D-serine
Glossary: O-ureido-L-serine = (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate
O-ureido-D-serine = (2R)-2-amino-3-[(carbamoylamino)oxy]propanoate
Other name(s): dcsC (gene name)
Systematic name: (2S)-2-amino-3-[(carbamoylamino)oxy]propanoate 2-epimerase
Comments: The enzyme employs a two-base mechanism, with a thiolate-thiol pair in the active site. It participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Kumagai, T., Koyama, Y., Oda, K., Noda, M., Matoba, Y. and Sugiyama, M. Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae. Antimicrob. Agents Chemother. 54 (2010) 1132–1139. [DOI] [PMID: 20086163]
2.  Dietrich, D., van Belkum, M.J. and Vederas, J.C. Characterization of DcsC, a PLP-independent racemase involved in the biosynthesis of D-cycloserine. Org. Biomol. Chem. 10 (2012) 2248–2254. [DOI] [PMID: 22307920]
[EC 5.1.1.19 created 2013]
 
 
EC 6.3.3.5     
Accepted name: O-ureido-D-serine cyclo-ligase
Reaction: O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + NH3 + ADP + phosphate
Glossary: O-ureido-D-serine = (2R)-2-amino-3-[(carbamoylamino)oxy]propanoate
Other name(s): dcsG (gene name)
Systematic name: O-ureido-D-serine cyclo-ligase (D-cycloserine-forming)
Comments: The enzyme participates in the biosynthetic pathway of D-cycloserine, an antibiotic substance produced by several Streptomyces species.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Kumagai, T., Koyama, Y., Oda, K., Noda, M., Matoba, Y. and Sugiyama, M. Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae. Antimicrob. Agents Chemother. 54 (2010) 1132–1139. [DOI] [PMID: 20086163]
2.  Uda, N., Matoba, Y., Kumagai, T., Oda, K., Noda, M. and Sugiyama, M. Establishment of an in vitro D-cycloserine-synthesizing system by using O-ureido-L-serine synthase and D-cycloserine synthetase found in the biosynthetic pathway. Antimicrob. Agents Chemother. 57 (2013) 2603–2612. [DOI] [PMID: 23529730]
[EC 6.3.3.5 created 2013]
 
 


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