The Enzyme Database

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EC 2.4.1.353     
Accepted name: sordaricin 6-deoxyaltrosyltransferase
Reaction: GDP-6-deoxy-α-D-altrose + sordaricin = 4′-O-demethylsordarin + GDP
For diagram of sordarin biosynthesis, click here
Glossary: sordaricin = (1R,3aR,4S,4aR,7R,7aR,8aR)-4-formyl-8a-(hydroxymethyl)-7-methyl-3-(propan-2-yl)-1,3a,4,4a,5,6,7,7a,8,8-decahydro-1,4-methanocyclopenta[f]indene-3a-carboxylic acid
Other name(s): SdnJ
Systematic name: GDP-6-deoxy-α-D-altrose:sordaricin 6-deoxy-D-altrosyltransferase
Comments: The enzyme, isolated from the fungus Sordaria araneosa, is involved in the biosynthesis of the glycoside antibiotic sordarin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Kudo, F., Matsuura, Y., Hayashi, T., Fukushima, M. and Eguchi, T. Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase. J. Antibiot. (Tokyo) 69 (2016) 541–548. [DOI] [PMID: 27072286]
[EC 2.4.1.353 created 2018]
 
 
EC 4.2.3.191     
Accepted name: cycloaraneosene synthase
Reaction: geranylgeranyl diphosphate = cycloaraneosene + diphosphate
For diagram of biosynthesis of fusicoccane diterpenoids, click here
Glossary: cycloaraneosene = (1R,3aR,9aS,10aR)-1,9a-dimethyl-4-methylene-7-(propan-2-yl)-1,2,3,3a,4,5,6,8,9,9a,10,10a-dodecahydrodicyclopenta[a,d][8]annulene
Other name(s): SdnA
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cycloaraneosene-forming)
Comments: Isolated from the fungus Sordaria araneosa. Cycloaraneosene is a precursor of the antibiotic sordarin.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Kudo, F., Matsuura, Y., Hayashi, T., Fukushima, M. and Eguchi, T. Genome mining of the sordarin biosynthetic gene cluster from Sordaria araneosa Cain ATCC 36386: characterization of cycloaraneosene synthase and GDP-6-deoxyaltrose transferase. J. Antibiot. (Tokyo) 69 (2016) 541–548. [DOI] [PMID: 27072286]
[EC 4.2.3.191 created 2017]
 
 
EC 4.2.3.215     
Accepted name: δ-araneosene synthase
Reaction: geranylgeranyl diphosphate = δ-araneosene + diphosphate
Glossary: δ-araneosene = (3aR,5E,9E)-3a,6,10-trimethyl-1-(propan-2-yl)-2,3,3a,4,7,8,11,12-octahydrocyclopenta[11]annulene
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase [cyclizing, δ-araneosene-forming]
Comments: Isolated from the fungus Colletotrichum gloeosporioidea. δ-Araneosene may be involved in the biosynthesis of dolasta-1(15),8-diene (see EC 4.2.3.214, dolasta-1(15),8-diene synthase) and cycloaraneosene (see EC 4.2.3.191, cycloaraneosene synthase).
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Bian, G., Rinkel, J., Wang, Z., Lauterbach, L., Hou, A., Yuan, Y., Deng, Z., Liu, T. and Dickschat, J.S. A clade II-D fungal chimeric diterpene synthase from Colletotrichum gloeosporioides produces dolasta-1(15),8-diene. Angew. Chem. Int. Ed. Engl. 57 (2018) 15887–15890. [DOI] [PMID: 30277637]
[EC 4.2.3.215 created 2023]
 
 


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