ExplorEnz: Search Results

Your query returned 4 entries. Printable version

1.1.1.134

Accepted name:

dTDP-6-deoxy-L-talose 4-dehydrogenase (NADP⁺)

Reaction:

dTDP-6-deoxy-β-L-talose + NADP⁺ = dTDP-4-dehydro-β-L-rhamnose + NADPH + H⁺

Glossary:

dTDP-4-dehydro-β-L-rhamnose = dTDP-4-dehydro-6-deoxy-β-L-mannose
dTDP-6-deoxy-β-L-talose = dTDP-β-L-pneumose

Other name(s):

thymidine diphospho-6-deoxy-L-talose dehydrogenase; TDP-6-deoxy-L-talose dehydrogenase; dTDP-6-deoxy-L-talose dehydrogenase (4-reductase); dTDP-6-deoxy-L-talose:NADP⁺ 4-oxidoreductase

Systematic name:

dTDP-6-deoxy-β-L-talose:NADP⁺ 4-oxidoreductase

Comments:

Oxidation on the 4-position of the hexose moiety takes place only while the substrate is bound to another enzyme that catalyses epimerization at C-3 and C-5.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37250-65-0

References:

1.	Gaugler, R.W. and Gabriel, O. Biological mechanisms involved in the formation of deoxy sugars. VII. Biosynthesis of 6-deoxy-L-talose. J. Biol. Chem. 248 (1973) 6041–6049. [PMID: 4199258]

[EC 1.1.1.134 created 1972]

1.1.1.339

Accepted name:

dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD⁺)

Reaction:

dTDP-6-deoxy-β-L-talose + NAD⁺ = dTDP-4-dehydro-β-L-rhamnose + NADH + H⁺

Glossary:

dTDP-4-dehydro-β-L-rhamnose = dTDP-4-dehydro-6-deoxy-β-L-mannose
dTDP-6-deoxy-β-L-talose = dTDP-β-L-pneumose

Other name(s):

tll (gene name)

Systematic name:

dTDP-6-deoxy-β-L-talose:NAD⁺ 4-oxidoreductase

Comments:

The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP⁺.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Nakano, Y., Suzuki, N., Yoshida, Y., Nezu, T., Yamashita, Y. and Koga, T. Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans. J. Biol. Chem. 275 (2000) 6806–6812. [DOI] [PMID: 10702238]

[EC 1.1.1.339 created 2012]

1.1.1.344

Accepted name:

dTDP-6-deoxy-L-talose 4-dehydrogenase [NAD(P)⁺]

Reaction:

dTDP-6-deoxy-β-L-talose + NAD(P)⁺ = dTDP-4-dehydro-β-L-rhamnose + NAD(P)H + H⁺

Glossary:

dTDP-4-dehydro-β-L-rhamnose = dTDP-4-dehydro-6-deoxy-β-L-mannose
dTDP-6-deoxy-β-L-talose = dTDP-β-L-pneumose

Other name(s):

tal (gene name)

Systematic name:

dTDP-6-deoxy-β-L-talose:NAD(P)⁺ 4-oxidoreductase

Comments:

The enzyme works equally well with NAD⁺ and NADP⁺.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

Karki, S., Yoo, H.G., Kwon, S.Y., Suh, J.W. and Kwon, H.J. Cloning and in vitro characterization of dTDP-6-deoxy-L-talose biosynthetic genes from Kitasatospora kifunensis featuring the dTDP-6-deoxy-L-lyxo-4-hexulose reductase that synthesizes dTDP-6-deoxy-L-talose. Carbohydr. Res. 345 (2010) 1958–1962. [DOI] [PMID: 20667525]

[EC 1.1.1.344 created 2013]

5.1.3.25

Accepted name:

dTDP-L-rhamnose 4-epimerase

Reaction:

dTDP-6-deoxy-β-L-talose = dTDP-β-L-rhamnose

Glossary:

dTDP-β-L-rhamnose = dTDP-6-deoxy-β-L-mannose
dTDP-6-deoxy-β-L-talose = dTDP-β-L-pneumose

Other name(s):

dTDP-4-L-rhamnose 4-epimerase; wbiB (gene name)

Systematic name:

dTDP-6-deoxy-β-L-talose 4-epimerase

Comments:

The equilibrium is strongly towards dTDP-β-L-rhamnose.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Yoo, H.G., Kwon, S.Y., Karki, S. and Kwon, H.J. A new route to dTDP-6-deoxy-L-talose and dTDP-L-rhamnose: dTDP-L-rhamnose 4-epimerase in Burkholderia thailandensis. Bioorg. Med. Chem. Lett. 21 (2011) 3914–3917. [DOI] [PMID: 21640586]

[EC 5.1.3.25 created 2012]