The Enzyme Database

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EC 2.3.1.205     
Accepted name: fumigaclavine B O-acetyltransferase
Reaction: acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A
For diagram of fumigaclavin alkaloid biosynthesis, click here
Glossary: fumigaclavine B = 6,8β-dimethylergolin-9-ol;
fumigaclavine A = 6,8β-dimethylergolin-9β-yl acetate
Other name(s): FgaAT
Systematic name: acetyl-CoA:fumigaclavine B O-acetyltransferase
Comments: The enzyme participates in the biosynthesis of fumigaclavine C, an ergot alkaloid produced by some fungi of the Trichocomaceae family.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Liu, X., Wang, L., Steffan, N., Yin, W.B. and Li, S.M. Ergot alkaloid biosynthesis in Aspergillus fumigatus: FgaAT catalyses the acetylation of fumigaclavine B. ChemBioChem 10 (2009) 2325–2328. [DOI] [PMID: 19672909]
[EC 2.3.1.205 created 2012]
 
 
EC 2.5.1.100     
Accepted name: fumigaclavine A dimethylallyltransferase
Reaction: fumigaclavine A + dimethylallyl diphosphate = fumigaclavine C + diphosphate
For diagram of fumigaclavin alkaloid biosynthesis, click here
Glossary: fumigaclavine A = 6,8β-dimethylergolin-9β-yl acetate;
fumigaclavine C = 2-(2-methylbut-3-en-2-yl)-6,8β-dimethylergolin-9β-yl acetate
Other name(s): FgaPT1
Systematic name: dimethylallyl-diphosphate:fumigaclavine A dimethylallyltransferase
Comments: Fumigaclavine C is an ergot alkaloid produced by some fungi of the Trichocomaceae family. Activity does not require any metal ions.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Unsöld, I.A. and Li, S.M. Reverse prenyltransferase in the biosynthesis of fumigaclavine C in Aspergillus fumigatus: gene expression, purification, and characterization of fumigaclavine C synthase FGAPT1. ChemBioChem 7 (2006) 158–164. [DOI] [PMID: 16397874]
[EC 2.5.1.100 created 2012]
 
 


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