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Your query returned 6 entries. Printable version
EC | 1.14.13.134 | ||||||||||||||||||||||
Transferred entry: | β-amyrin 11-oxidase. Now EC 1.14.14.152, β-amyrin 11-oxidase | ||||||||||||||||||||||
EC | 1.14.13.173 | ||||||||||||||||||||||
Transferred entry: | 11-oxo-β-amyrin 30-oxidase. Now EC 1.14.14.115, 11-oxo-β-amyrin 30-oxidase. | ||||||||||||||||||||||
EC | 1.14.14.115 | ||||||||||||||||||||||
Accepted name: | 11-oxo-β-amyrin 30-oxidase | ||||||||||||||||||||||
Reaction: | 11-oxo-β-amyrin + 3 O2 + 3 [reduced NADPH—hemoprotein reductase] = glycyrrhetinate + 3 [oxidized NADPH—hemoprotein reductase] + 4 H2O (overall reaction) (1a) 11-oxo-β-amyrin + O2 + [reduced NADPH—hemoprotein reductase] = 30-hydroxy-11-oxo-β-amyrin + [oxidized NADPH—hemoprotein reductase] + H2O (1b) 30-hydroxy-11-oxo-β-amyrin + O2 + [reduced NADPH—hemoprotein reductase] = glycyrrhetaldehyde + [oxidized NADPH—hemoprotein reductase] + 2 H2O (1c) glycyrrhetaldehyde + O2 + [reduced NADPH—hemoprotein reductase] = glycyrrhetinate + [oxidized NADPH—hemoprotein reductase] + H2O |
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For diagram of glycyrrhenate biosynthesis, click here | |||||||||||||||||||||||
Other name(s): | CYP72A; CYP72A154; 11-oxo-β-amyrin 30-monooxygenase | ||||||||||||||||||||||
Systematic name: | 11-oxo-β-amyrin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (30-hydroxylating) | ||||||||||||||||||||||
Comments: | A cytochrome P-450 (heme-thiolate) protein. The enzyme from the plant Glycyrrhiza uralensis (licorice) is involved in the biosynthesis of the triterpenoid saponin glycyrrhizin. The enzyme from the plant Medicago truncatula can also hydroxylate β-amyrin. | ||||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||||||||
References: |
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EC | 1.14.14.152 | ||||||||||||||||||||||
Accepted name: | β-amyrin 11-oxidase | ||||||||||||||||||||||
Reaction: | β-amyrin + 2 [reduced NADPH—hemoprotein reductase] + 2 O2 = 11-oxo-β-amyrin + 2 [oxidized NADPH—hemoprotein reductase] + 3 H2O (overall reaction) (1a) β-amyrin + [reduced NADPH—hemoprotein reductase] + O2 = 11α-hydroxy-β-amyrin + [oxidized NADPH—hemoprotein reductase] + H2O (1b) 11α-hydroxy-β-amyrin + [reduced NADPH—hemoprotein reductase] + O2 = 11-oxo-β-amyrin + [oxidized NADPH—hemoprotein reductase] + 2 H2O |
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For diagram of glycyrrhenate biosynthesis, click here | |||||||||||||||||||||||
Other name(s): | CYP88D6 | ||||||||||||||||||||||
Systematic name: | β-amyrin,[reduced NADPH—hemoprotein reductase]:oxygen oxidoreductase (hydroxylating) | ||||||||||||||||||||||
Comments: | A cytochrome P-450 (heme-thiolate) protein from the plant Glycyrrhiza uralensis (Chinese licorice) that participates in the glycyrrhizin biosynthesis pathway. The enzyme is also able to oxidize 30-hydroxy-β-amyrin to 11α,30-dihydroxy-β-amyrin but this is not thought to be part of glycyrrhizin biosynthesis. | ||||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||||||||
References: |
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EC | 3.2.1.128 | ||||||||||||||||||||||
Accepted name: | glycyrrhizin hydrolase | ||||||||||||||||||||||
Reaction: | glycyrrhizin + H2O = β-D-glucuronosyl-(1→2)-D-glucuronate + glycyrrhetinate | ||||||||||||||||||||||
Glossary: | glycyrrhizin = glycyrrhizinate glycyrrhetinate = 3-β-glycyrrhetinate = 3β-hydroxy-11-oxoolean-12-en-30-oate |
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Other name(s): | glycyrrhizinate β-glucuronidase; glycyrrhizin β-hydrolase; glycyrrhizinic acid hydrolase | ||||||||||||||||||||||
Systematic name: | glycyrrhizinate glucuronosylhydrolase | ||||||||||||||||||||||
Comments: | The enzyme from Aspergillus niger is specific for the hydrolysis of the triterpenoid glycoside glycyrrhizin from roots of Glycyrrhiza sp. | ||||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 102484-56-0 | ||||||||||||||||||||||
References: |
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EC | 5.4.99.39 | ||||||||||||||||||||||
Accepted name: | β-amyrin synthase | ||||||||||||||||||||||
Reaction: | (3S)-2,3-epoxy-2,3-dihydrosqualene = β-amyrin | ||||||||||||||||||||||
For diagram of beta-amyrin and soysapogenol biosynthesis, click here | |||||||||||||||||||||||
Other name(s): | 2,3-oxidosqualene β-amyrin cyclase; AsbAS1; BPY; EtAS; GgbAS1; LjAMY1; MtAMY1; PNY; BgbAS | ||||||||||||||||||||||
Systematic name: | (3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, β-amyrin-forming) | ||||||||||||||||||||||
Comments: | Some organism possess a monofunctional β-amyrin synthase [3,4,6-11], other have a multifunctional enzyme that also catalyses the synthesis of α-amyrin (EC 5.4.99.40) [5] or lupeol (EC 5.4.99.41) [6]. | ||||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||||||||||||||||||||||
References: |
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